Laser guide stars (LGS) are used in many adaptive optics systems to extend sky coverage. The most common wavefront sensor used in combination with a LGS is a Shack-Hartmann wavefront sensor (SHWFS). The ShackHartmann has a major disadvantage for extended source wavefront sensing because it directly samples the image. In this proceeding we propose to use the generalized-Optical Differentation Wavefront Sensor (g-ODWFS) a wavefront sensor for wavefront sensing of LGS. The g-ODWFS uses only 4 pixels per sub-aperture, has little to no aliasing noise and therefore no spurious low-order errors and has no need for centroid gain calibrations. In this proceeding we show the results of simulations that compare the g-ODWFS with the SHWFS.